Wael Asaad, MD, PhD

Functional and General Neurosurgery

Dr. Wael Asaad received his undergraduate degree from Amherst College in 1993, then earned a Ph.D in Systems Neuroscience from M.I.T. in 2001, and his M.D. from Yale University in 2003. Dr. Asaad completed a general surgery internship and neurosurgical residency at the Massachusetts General Hospital. During his residency, he undertook additional training in functional neurosurgery. In 2011, he joined the department of neurosurgery at the Brown University Alpert Medical School.

Dr. Asaad's clinical interests include functional neurosurgery for movement disorders and psychiatric disease, traumatic brain injury, and general neurosurgery of the brain and spine.

DBS Patient Guide (high-resolution pdf - 8MB)

DBS Patient Guide (lower-resolution pdf - 1MB)

Dr. Asaad's basic science interests focus on the ways in which neuronal circuits in the frontal cortex and basal ganglia underlie visual-motor learning, memory and decision-making, and how a better understanding of these might lead to strategies to alleviate the cognitive aspects of psychiatric and neurological diseases, including traumatic brain injury and stroke.

Lab Web Site



Action-Initiation in the Human Dorsal Anterior Cingulate Cortex
Srinivasan Lakshminarayan, Wael F. Asaad, Daniel T. Ginat, John T. Gale, Darin D. Dougherty, Ziv M. Williams, Terrence J. Sejnowski & Emad N. Eskandar
PLoS ONE, 2013, in-press

Human Dorsal Anterior Cingulate Cortex Neurons Mediate Ongoing Behavioural Adaptation
Sameer A. Sheth, Matt K. Mian, Shaun R. Patel, Wael F. Asaad, Ziv M. Williams, Darin D. Dougherty, George Bush & Emad N. Eskandar
Nature, 2012, Vol. 488 (7410), pp. 218-221

Encoding of both Positive and Negative Reward Prediction Errors by Neurons of the Primate Prefrontal Cortex and Caudate Nucleus
Wael F. Asaad & Emad N. Eskandar
Journal of Neuroscience, 2011, Vol. 31 (49), pp. 17772-17787

A Neural Model of Flexible Sensori-Motor Mapping: Learning and Forgetting on Multiple Time-Scales
Stefano Fusi, Wael F. Asaad, Earl K. Miller, & Xiao-Jing Wang
Neuron, 2007, Vol. 54, pp. 319-333

Task-Specific Neural Activity in the Primate Prefrontal Cortex
Wael F. Asaad, Gregor Rainer, & Earl K. Miller
Journal of Neurophysiology, 2000, Vol. 84, pp. 451-459

Attenuation of NMDA Receptor Activity and Neurotoxicity by Nitroxyl Anion (NO-)
Won Ki Kim, Yun-Beum Choi, Posina V. Rayadu, Prajnan Das, Wael Asaad, Derrick R. Arnelle, Jonathan S. Stamler, & Stuart A. Lipton
Neuron, 1999, Vol.24, pp. 461-469

Neural Activity in the Primate Prefrontal Cortex during Associative Learning
Wael F. Asaad, Gregor Rainer, & Earl K. Miller
Neuron, 1998, Vol. 21, pp. 1399-1407

Selective Representation of Relevant Information in the Primate Prefrontal Cortex
Gregor Rainer, Wael F. Asaad & Earl K. Miller
Nature, 1998, Vol.393, pp. 577-579

Memory Fields of Neurons in the Primate Prefrontal Cortex
Gregor Rainer, Wael F. Asaad & Earl K. Miller
Proc. Natl. Acad. Sci., USA, 1998, Vol.95, pp. 15008-15013

Concentric Orientation Summation in Human Form Vision
Hugh R. Wilson, Frances W. Wilkinson & Wael Asaad
Vision Research, 1997, Vol. 37 No.17, pp. 2325-2330


Predictors of cranioplasty complications in stroke and trauma patients
Brian P. Walcott, Churl-Su Kwon, Sameer A. Sheth, Corey R. Fehnel, Robert M. Koffie, Wael F. Asaad, Brian V. Nahed & Jean-Valery Coumans
Journal of Neurosurgery, 2013, in-press

Bilateral Hemicraniectomy in Non-Penetrating Traumatic Brain Injury
Brian P. Walcott, Brian V. Nahed, Sameer A. Sheth, Vijay Yanamadala, James Caracci & Wael F. Asaad
Journal of Neurotrauma, 2012, Vol. 29 (10), pp. 1879-1885

The use of intra-operative blood gas analysis in the investigation of suspected iatrogenic vascular injury: case report
Brian P. Walcott, Kristopher T. Kahle, Brian V. Nahed, Jean-Valery Coumans & Wael F. Asaad
European Spine Journal, 2012, Vol. 21 (S4), pp. S492-494

Craniectomy for Malignant Cerebral Infarction: Prevalence and Outcomes in U.S. Hospitals
Brian P. Walcott, Elena V. Kuklina, Brian V. Nahed, Mary G. George, Kristopher T. Kahle, J. Marc Simard, Wael F. Asaad & Jean-Valery C.E. Coumans
PLoS ONE, 2011, Vol. 6 (12), pp. e29193

Fourth ventricular neurocystercercosis presenting with acute hydrocephalus
Brian W. Hanak, Brian P. Walcott, Pamela S. Jones, Brian V. Nahed, William E. Butler & Wael F. Asaad
Journal of Clinical Neuroscience, 2011, Vol. 18 No. 6 pp. 867-869

Temporal bone chondroblastoma with secondary aneurysmal bone cyst presenting as an intracranial mass with clinical seizure activity
Christopher J. Stapleton, Brian P. Walcott, Katy R. Linskey, Kristopher T. Kahle, Brian V. Nahed & Wael F. Asaad
Journal of Clinical Neuroscience, 2011, Vol. 18 (6), pp. 857-860

Risk Factors for Hemorrhage during Microelectrode Guided Deep Brain Stimulation and the Introduction of an Improved Microelectrode Design
Sherona Ben-Haim, Wael F. Asaad, John T. Gale & Emad N. Eskandar
Neurosurgery, 2009, Vol. 64 (4), pp. 754-762

Prospective Assessment of Stereotactic Ablative Surgery for Intractable Major Depression
Don C. Shields, Wael F. Asaad, Emad N. Eskandar, Felipe A. Jain, G. Reese Cosgrove, Alice W. Flaherty, Edward H. Cassem, Bruce H. Price, Scott L. Rauch, & Daniel D. Dougherty
Biological Psychiatry, 2008, Vol. 64, pp. 449-454

Tools, Devices & Protocols

Studying Task-Related Activity of Individual Neurons in the Human Brain
Shaun R. Patel, Sameer A. Sheth, Clarissa Martinez-Rubio, Matthew K. Mian, Wael F. Asaad, Jason L. Gerrard, Churl-Su Kwon, Darin D. Dougherty, Alice W. Flaherty, Benjamin D. Greenberg, John T. Gale, Ziv M. Williams & Emad N. Eskandar
Nature Protocols, 2013, in-press

High-performance execution of psychophysical tasks with complex visual stimuli in MATLAB
Wael F. Asaad, Navaneethan Santhanam, Steven M. McClellan & David J. Freedman
Journal of Neurophysiology, 2013, Vol. 109, pp. 249-260

A Flexible Software Tool for Temporally-Precise Behavioral Control in Matlab
Wael F. Asaad & Emad N. Eskandar
Journal of Neuroscience Methods, 2008, Vol. 174, pp. 245-258

Achieving Behavioral Control with Millisecond Resolution in a High-Level Programming Environment
Wael F. Asaad & Emad N. Eskandar
Journal of Neuroscience Methods, 2008, Vol. 173, pp. 235-240

Reviews, Commentary & Book Chapters

Operative management of brainstem cavernous malformations
Wael F. Asaad, Brian P. Walcott, Brian V. Nahed & Christopher S. Ogilvy
Neurosurgical Focus, 2010, Vol. 29 No. 3 E10

Intraoperative Neurophysiologic Monitoring of the Cranial Nerves and Brainstem
Wael F. Asaad, Mirela V. Simon & Emad N. Eskandar
Handbook of Neuromonitoring, 2010, pp 299-322, Mirela V. Simon, Ed, Demos Medical Publishing

The Surgical Management of Trigeminal Neuralgia
Wael F. Asaad & Emad N. Eskandar
Bonica’s Management of Pain, 4th edition, 2009, Fishman, Ballantyne & Rathmell, Eds., Lippincott, Williams & Wilkins, Pub.

The Movers and Shakers of Deep Brain Stimulation
Wael Asaad & Emad Eskandar
Nature Medicine, 2008, Vol. 14 No. 1, pp. 17-19

Deep Brain Stimulation for Obsessive Compulsive Disorder
Wael F. Asaad & Emad N. Eskandar
NeuroEngineering, 2007, pp. 91-96, D. DiLorenzo & J. Bronzino, eds. CRC Press

The Prefrontal Cortex: Conjunction and Cognition
Earl K. Miller & Wael F. Asaad
The Handbook of Neuropsychology (2nd ed.), 2002, pp. 29-54. F. Boller & J. Grafman, eds. Elsevier Press


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