Functional Neurosurgery Research Studies

We are proud to host an array of clinical trials for our patients so that they can take advantage of some of the newest treatment options for their conditions, and test some of the most recent technological innovations in neurosurgery. Our clinical trial efforts are assisted by collaborations with the Rhode Island Hospital (Level 1 Trauma Center) & Hasbro Children’s Hospital Emergency Departments, the Brown University Health Cancer Center, and the Norman Prince Spine Institute.

Below are some of our ongoing clinical trials:

BRT-DA01 cell therapy for Parkinson’s Disease (Enrolling in early 2025); PI Dr. Wael F. Asaad, MD, PhD

RESTORE: Deep Brain Stimulation of the Cerebellum to Enhance Motor Recovery after Stroke ENROLLING Subjects; PI Dr. Wael F. Asaad, MD, PhD

RESTORE is a multi-center trial testing the safety and efficacy of deep brain stimulation of the cerebellum to improve hand function after stroke.

ADvance-II Study – Closed; Site PI Dr. Wael Asaad, MD, PhD

ADvance-II is a multi-center clinical research trial investigating the efficacy of deep brain stimulation (DBS) for patients with mild Alzheimer’s disease. The study is sponsored by Functional Neuromodulation. DBS involves a brain implant which is being studied as a possible way to improve function in patients with Alzheimer’s disease. While the use of DBS for Alzheimer’s disease is new, DBS is FDA-approved as an effective treatment for other neurodegenerative diseases, such as Parkinson’s. The device is implanted just under the skin on the chest, and small leads are placed in the memory center of the brain to deliver electrical impulses to activate part of the brain that is affected by Alzheimer’s disease. We are looking to determine if this device will improve long-term function in patients with mild Alzheimer’s who are at least 65 years of age.