Rapid motor fluctuations reveal short-timescale neurophysiological biomarkers of Parkinson’s disease

Minkyu AhnShane LeePeter M LauroErin L SchaefferUmer Akbar  and Wael F Asaad 

Identifying neural activity biomarkers of brain disease is essential to provide objective estimates of disease burden, obtain reliable feedback regarding therapeutic efficacy, and potentially to serve as a source of control for closed-loop neuromodulation. In Parkinson’s disease (PD), microelectrode recordings (MER) are routinely performed in the basal ganglia to guide electrode implantation for deep brain stimulation (DBS). While pathologically-excessive oscillatory activity has been observed and linked to PD motor dysfunction broadly, the extent to which these signals provide quantitative information about disease expression and fluctuations, particularly at short timescales, is unknown. Furthermore, the degree to which informative signal features are similar or different across patients has not been rigorously investigated. We sought to determine the extent to which motor error in PD across patients can be decoded on a rapid timescale using spectral features of neural activity.”

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Wael F. Asaad, MD, PhD

Sidney A. Fox and Dorothea Doctors Fox Professor of Ophthalmology and Visual Science
Professor of Neurosurgery and Neuroscience
Vice-Chair, Research
Director, Functional and Epilepsy Neurosurgery Program
Director, Laboratory for Neurophysiology and Neuromodulation
Associate Director, Neurosurgery Residency Training Program
Director, Fellowship in Functional & Epilepsy Neurosurgery