Rapid motor fluctuations reveal short-timescale neurophysiological biomarkers of Parkinson’s disease

Minkyu AhnShane LeePeter M LauroErin L SchaefferUmer Akbar  and Wael F Asaad 

Identifying neural activity biomarkers of brain disease is essential to provide objective estimates of disease burden, obtain reliable feedback regarding therapeutic efficacy, and potentially to serve as a source of control for closed-loop neuromodulation. In Parkinson’s disease (PD), microelectrode recordings (MER) are routinely performed in the basal ganglia to guide electrode implantation for deep brain stimulation (DBS). While pathologically-excessive oscillatory activity has been observed and linked to PD motor dysfunction broadly, the extent to which these signals provide quantitative information about disease expression and fluctuations, particularly at short timescales, is unknown. Furthermore, the degree to which informative signal features are similar or different across patients has not been rigorously investigated. We sought to determine the extent to which motor error in PD across patients can be decoded on a rapid timescale using spectral features of neural activity.”

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Wael F. Asaad, MD, PhD

Sidney A. Fox and Dorothea Doctors Fox Associate Professor of Ophthalmology and Visual Science
Associate Professor of Neurosurgery and Neuroscience
Director, Functional Neurosurgery and Epilepsy Program
Director, Cognitive Neuro-physiology and Neuro-modulation Laboratory