The Chen Laboratory

The Chen lab is dedicated to advancing our understanding of the molecular pathogenesis of glioblastoma, the most common form of brain cancer in adults. This cancer remains one of the deadliest of human cancers. We advance this understanding through an integrated approach, incorporating laboratory investigations, clinical studies, and computational modeling. We aim to translate this understanding into therapeutic and biomarker platforms through bio-engineering and clinical trials. Current projects in the laboratory include: electric field therapy through surgically implanted electrodes, surgical delivery of microRNAs, laser interstitial therapy, and high intensity focused ultrasound delivered through surgical devices.

Director

1. A public defender’s fight against brain cancer: Michelle Alves’ journey of resilience: https://www.wcvb.com/article/rhode-island-brain-cancer-fight-glioblastoma-treatment-brown-university-health/62842960
2. Tiny brain implants aim potent radiation at tumors: https://pbn.com/tiny-brain-implants-aim-potent-radiation-at-tumors/?bypass=67c083acd8c7c
3. First patient in Rhode Island receives novel gamma tile treatment for glioblastoma: https://turnto10.com/features/health-landing-page/first-patient-rhode-island-novel-gamma-tile-treatment-glioblastoma-brain-cancer-diagnosis-doctors-nurses-february-10-2025
4. William Hart: Winning the Battle Against Glioblastoma Choosing the Brown University Health Cancer Institute for His Glioblastoma Care: William Hart: Winning the Battle Against Glioblastoma | Brown University Health
5. Brown brain tumor specialist discusses deadly cancer glioblastoma: https://www.abc6.com/brown-brain-tumor-specialist-discusses-deadly-cancer-glioblastoma/