The Neurophysiology & Neuromodulation Laboratory studies the mechanisms of learning, memory and decision-making using psychophysical and neurophysiological techniques in animals and humans. Our goals are to improve the basic understanding of rapid behavioral plasticity in the frontal cortex, basal ganglia and thalamus, while simultaneously advancing neuromodulation for neurological and psychiatric disease.
The laboratory is situated across the departments of Neurosurgery and Neuroscience. Facilities are located both at Brown University and Rhode Island Hospital. We are grateful for the generous support of the Brown Institute for Brain Science, the Norman Prince Neurosciences Institute, the Brown University Departments of Neuroscience & Neurosurgery, and Brown University Alpert Medical School.
Current research projects include: mechanisms of reinforcement learning in the prefrontal cortex and basal ganglia, neurophysiology of the vim nucleus of the thalamus during motor learning, detection of neurophysiological biomarkers of Parkinson’s Disease and closed-loop DBS, the effects of DBS on cognition and motor learning, attention and oculomotor behavior in movement disorders, and data synthesis and event prediction in the Neuro ICU.
The laboratory has received support from our patients, the significant contributions of our collaborators, and generous funding from these agencies and foundations: The Doris Duke Charitable Foundation, The Neurosurgery Research and Education Foundation, The National Institutes of Health, A McDonnell-Pew grant from the J.S. McDonnell Foundation, An MGH-ECOR Tosteson Award, The Michael J. Fox Foundation, The Norman Prince Neurosciences Institute, The Roddy Holden Foundation, Faxon Friends.